Sick Sinus Syndrome in HCN1-Deficient Mice
نویسندگان
چکیده
منابع مشابه
Sick sinus syndrome in HCN1-deficient mice.
BACKGROUND Sinus node dysfunction (SND) is a major clinically relevant disease that is associated with sudden cardiac death and requires surgical implantation of electric pacemaker devices. Frequently, SND occurs in heart failure and hypertension, conditions that lead to electric instability of the heart. Although the pathologies of acquired SND have been studied extensively, little is known ab...
متن کاملSick Sinus Syndrome in HCN 1 - Deficient Mice Running title : Fenske
1 Center for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung Department Pharmazie, Ludwig Maximilians University, Munich, Germany; Medizinische Klinik und Poliklinik I, Klinikum Großhadern, Ludwig Maximilians University, Munich, Germany; DZHK (German Center for Cardiovascular research), partner site Munich Heart Alliance, Munich, Germany; Max-Planck-Institut für Psychiatrie Mü...
متن کاملThe sick sinus syndrome.
1. a. SSS b. SA block c. SA arrest Sick sinus syndrome is a disorder characterized by a dysfunctional sinus node. It is often idiopathic and a result of degenerative fibrosis of nodal tissue. Certain disorders such as amyloidosis, connective tissue disease, Chagas disease, and hemochromatosis are examples of intrinsic causes. Hypertensive heart disease and cardiomyopathies account for a smaller...
متن کاملIatrogenic sick sinus syndrome.
A 50-year-old university professor originally from South America had a 3-day history of paroxysmal attacks of rapid palpitations accompanied by near syncope and followed by transient flushing of her head and neck. She had a history of rheumatic mitral valve stenosis due to rheumatic fever at age 15, for which successful mitral commissurotomy was performed at age 36. Subsequently, recurrent atta...
متن کاملSick sinus syndrome in children.
The ages of 6 male patients with the sick sinus syndrome ranged from 10-15 years when their symptoms began. At rest all had a heart rate of 60/min or less. Two had syncopal attacks which threatened life; 1 had only attacks of dizziness; the other 3 had no syncopal attacks but had recurrent attacks of supraventricular tachycardia ('brady-tachycardia syndrome') which were more resistant to drug t...
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ژورنال
عنوان ژورنال: Circulation
سال: 2013
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.113.003712